Treatment for Low Testosterone 3 About one-half of XXY males' chromosomes have low testosterone levels. 4 These levels can be raised by taking supplemental testosterone Hormone replacement therapy (HRT) or testosterone replacement therapy is useful to help those with Klinefelter Syndrome or XXY. The medication is necessary to bring our low testosterone level to its proper level Treatment for Klinefelter syndrome is based on signs and symptoms and may include: Testosterone replacement therapy. Starting at the time of the usual onset of puberty, testosterone replacement therapy can be given to help stimulate changes that normally occur at puberty, such as developing a deeper voice, growing facial and body hair, and.
Testosterone treatment and thrombotic outcomes in Klinefelter syndrome (KS). a Testosterone treatment as a time-varying covariate with adjustment for birth year. b Adjusted for birth year and use of antidiabetics, antihypertensives, statins, platelet inhibitors, and anticoagulation therapy as time-varying covariates hypogonadism, Klinefelter syndrome, review article, testosterone treatment 1 | INTRODUCTION Taking care of boys and men with Klinefelter syndrome (KS; 47,XXY) presents itself with a number of challenges. Despite being present in approximately 1:600 of male births (150 per 100,000 live born boys Effects of Testosterone Replacement Therapy (TRT) The primary effects of Klinefelter's Syndrome (KS) are low testosterone and infertility. If testosterone levels are below the normal range, testosterone replacement therapy (TRT) is typically prescribed. Testosterone replacement will not improve fertility Testosterone treatment should normally be continued throughout life, although the dose may need to be adjusted later in life. There is no evidence for a male menopause, and therefore no age at which testosterone should routinely be stopped. The Klinefelter's Syndrome Clinic 28th January 2021 In KF adults, the benefits of testosterone therapy overwhelmingly relate to sexual health—normal libido, erections. Therapy also increases energy, muscle mass and strength. That's true as well in KF adolescent boys. But it can be hard to know what effects to expect in treating them
Boys with KS are often in need of speech therapy, and many suffer from learning disability and may benefit from special education. Medical treatment is mainly testosterone replacement therapy to alleviate acute and long-term consequences of hypogonadism as well as treating or preventing the frequent comorbidity The aim was to define the true incidence of gynaecomastia in adolescent boys with Klinefelter syndrome (KS) and to observe testosterone treatment effects on its duration by examination of the prospectively collected data from a specialist referral clinic for boys with KS, with comparison being made with KS boys identified by a historical newborn chromosome screening programme, together with chromosomally normal controls Testosterone Replacement Therapy (TRT) TRT involves testosterone administered as gels, skin patches or injections. Gel preparations are popular as they work well and are easy to use, avoiding the need for injections, particularly in children Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology Claus H. Gravholt,1,2 Simon Chang,1,3 Mikkel Wallentin,4,5 Jens Fedder,6 Philip Moore,7 and Anne Skakkebæk2,8 1Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, 8000 Aarhus C, Denmark; 2Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark
The purpose of this work is a presentation of cases of persons with Klinefelter Syndrome where, most probably--as a result of testosterone supplementation therapy, some aggressive behaviours occurred requiring implementation of pharmacotherapy and psychiatric hospitalisation When a diagnosis is made, treatment is based on the signs and symptoms present in each person.The first step which gives the opportunity to deal with the negative consequences of the Klinefelter syndrome, initially undertaken by the doctors, is to balance the testosterone deficiency Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue. The effects of Klinefelter syndrome vary, and not everyone has the same signs and.
Physical Therapy. Dreamstime. One of the things an individual with Klinefelter syndrome may experience is reduced muscle mass and motor control. This is due, in part, to the lack of testosterone present in Klinefelter syndrome patients. Physical therapy can be a helpful tool to help build muscle mass and regain some motor control Nebido® is the first long-acting testosterone injection for the treatment of male hypogonadism. Long term treatment therapy with Nebido® increases the improvement of erectile dysfunction and sexual mood, metabolic syndrome, muscle mass and strength Treatment of Klinefelter Syndrome. It's never too late to treat Klinefelter, but the earlier you start, the better. One common treatment is testosterone replacement therapy. It can start at. Treatments for Klinefelter syndrome. There's no cure for Klinefelter syndrome, but some of the problems associated with the condition can be treated if necessary. Possible treatments include: testosterone replacement therapy; speech and language therapy during childhood to help with speech developmen Effect of treatment with testosterone in Klinefelter syndrome T-KS males had smaller hip circumference, lower total body fat percentage, and a tendency towards higher lean body mass and lower total fat mass compared with U-KS (Table 2)
Treatment. There are many different treatment options for men that have Klinefelter's Syndrome in order to overcome learning, social, and physical problems that come with the disease. One of the major treatments recommended by physicians is to have testosterone replacement in order to increase the physical male characteristics, such as more. Testosterone replacement therapy: Since males with Klinefelter syndrome don't produce enough testosterone, undergoing testosterone replacement therapy at the onset of puberty can allow a boy to. Klinefelter syndrome is a chromosomal condition in boys and men that can affect physical and intellectual development. Most commonly, affected individuals are taller than average are unable to father biological children (infertile); however the signs and symptoms of Klinefelter syndrome vary among boys and men with this condition. In some cases, the features of the condition are so mild that. Testosterone replacement therapy (TRT) works by increasing a guy's testosterone levels into the normal range. This can help someone with Klinefelter syndrome develop bigger muscles, a deeper voice, growth of the penis, and facial and body hair
Klinefelter syndrome (KS; 47,XXY) is the most common sex chromosome abnormality in males (150 per 100,000 males). The condition leads to hypergonadotropic hypogonadism and ever since the condition was described approximately 80 years ago, testosterone treatment has been the cornerstone in care for individuals with KS How is Klinefelter Syndrome Treated? If testosterone levels are abnormally low, treatment with testosterone during and after adolescence may help many of the psychological symptoms and may increase secondary sex characteristics. If breast enlargement is a long-term problem, it may be treated surgically. Achieving fertility is more difficult Klinefelter syndrome . The treatment for this condition is based on the signs and symptoms of the following: Testosterone replacement therapy. It starts at the beginning of puberty to help promote changes that naturally occur during puberty, such as evolving facial and body hair, developing an extensive voice, and increasing muscle mass and. Limited information about the treatment of adults with Klinefelter syndrome is available; however, research has shown that continued testosterone injections, even if begun in adulthood, can be beneficial to those seeking treatment and may continue to help with hypogonadism, low libido (sex drive), and psychosocial issues
Klinefelter syndrome (KS) is the most frequent chromosome disorder in men, exhibiting a karyotype of 47,XXY. Symptoms in KS are highly variable. Nevertheless, frequent characteristics are small testes, azoospermia and hypergonadotropic hypogonadism. Testosterone therapy only in the presence of hypogonadism (follow guidelines for. Klinefelter syndrome is one of the most common chromosome conditions in newborns. It affects between 1 in 500 and 1 in 1,000 newborn males. Variants of the disease with three, four, or more extra.
Continued treatment throughout life helps prevent long-term health problems. Testosterone replacement does not cure infertility, however. Infertility treatments require specialized—and costly—techniques, but some men with Klinefelter syndrome have been able to father children Regular testosterone injections are often the treatment of choice for those with Klinefelter syndrome. This eMedTV article provides an overview of testosterone treatment for Klinefelter syndrome, including information on side effects Where Klinefelter's syndrome is suspected, blood tests will be carried out to assess levels of testosterone and gonadotrophins (luteinising hormone and follicle stimulating hormone). In patients with Klinefelter's syndrome, blood tests characteristically show a low testosterone level, high sex hormone binding globulin (SHBG) and raised. Klinefelter syndrome is thought to occur in 1 in every 500 or 1 in every 1000 males born in Australia each year. WHAT IS KLINEFELTER SYNDROME? testosterone treatment Sexuality is normal although men with Klinefelter syndrome are unable to produce sperm and are usually infertile
lacono G. Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's Syndrome J Clin Endocrinol Metab , 64 ( 1987 ) , pp. 32 - 3 1. Introduction. Mortality is increased in 47, XXY Klinefelter syndrome (KS) due to overall increased morbidity. This includes an up to 8-fold increased risk of venous thromboembolism (VTE) [, , ] and 2-fold increased risk for arterial thrombosis (ATE) [1,3,4].Men with KS have hypergonadotropic hypogonadism which in most cases lead to initiation of continuous testosterone treatment [5,6] Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys With Klinefelter Syndrome; The Role of Hypogonadism in Klinefelter Syndrome; Clinical Practice Guideline: Testosterone Therapy in Men with Hypogonadism; Mental Health. Autism and social anxiety in children with sex chromosome trisomies: an observational study
Klinefelter syndrome (sometimes called Klinefelter's, KS or XXY) is where boys and men are born with an extra X chromosome. The exact cause is not known but KS is not inherited / hereditary. Some of the main signs and symptoms include small and firm testes, reduced testosterone production, subfertility, and issues with intellectual and physical. Klinefelter syndrome treatment. Testosterone therapy can help with many of the symptoms of Klinefelter syndrome. This treatment should begin at puberty or as soon after as possible. Men with Klinefelter syndrome can now have children, if they want, with new forms of in-vitro fertilisation. For example, a single sperm can be injected into a. For example, guys with Klinefelter syndrome may be more likely to get some types of cancer and other diseases, like type 2 diabetes and osteoporosis, a condition where the bones become weaker later in life. As men, most guys with Klinefelter syndrome can have sex, usually with the help of testosterone treatment Klinefelter syndrome (KS), karyotype 47, XXY, is a common cause of hypogonadism in males. Patients with this condition often experience symptoms of gonadal failure, which can precipitate gender identity challenges. Treatment with testosterone replacement therapy (TRT) can combat these symptoms by improving sexual function, muscle mass, bone health, and virilization, thereby enhancing the.
Klinefelter Syndrome (KS) is the most frequent sex chromosome disorder in males. Due to hypergonadotropic hypogonadism, treatment with testosterone replacement therapy (TRT) is commonly indicated. There are no international guidelines for the most appropriate TRT in KS Klinefelter Syndrome can't be cured. Instead, you'll have lifelong testosterone therapy to help maintain general wellbeing. In Australia, testosterone therapy is available as injections, gels, creams, patches, and tablets, and works very well for men with testosterone deficiency. Your doctor or an endocrinologist can supervise testosterone. You may need testosterone therapy (TT) if you have Low-T. Both the FDA and the AUA suggest that TT be used to treat conditions you are born with, such as Klinefelter syndrome. You also may need TT if you harm or lose your testicles. If your testicles are removed because of a sickness such as cancer, you may need TT
, iatrogenic following surgery for testicular cancer, pharmacologically induced by gonadotropin-releasing hormone during prostate cancer treatment, or a natural consequence of aging During puberty we discuss the appropriate timing for considering testosterone treatment, as well as issues surrounding fertility. We may do blood tests in infants as part of an assessment of whether there would be a benefit of testosterone treatment. Klinefelter Syndrome Center
A more recent concern arises from the practice that some men with Klinefelter syndrome are nowadays treated with long-term testosterone substitutions. Clinical studies hitherto conducted with a focus on testosterone substitution therapy in men with hypogonadism did not indicate an increased malignization rate of prostate tissue [ 26 ] † Gynaecomastia is a common feature in Klinefelter syndrome men. † Hypogonadism occurs from mid-puberty onwards with the absence of the usual rise in testosterone levels. What is New: † The incidence of pubertal gynaecomastia in Klinefelter syndrome is not different from typically developing boys Treatments For Klinefelter Syndrome-There is no such cure for Klinefelter syndrome. However, some problems associated with it can be treated if necessary. The treatments are possible. Include the following-Testosterone Replacement Therapy (TRT). Physiotherapy to help build muscle and increase strength Klinefelter syndrome puts males at greater risk of breast cancer, other cancers and diseases, problems with blood vessels, problems with sexual function, and osteoporosis (weak bones) later in life. Most boys with Klinefelter syndrome can have sex when they become men, usually with the help of testosterone treatment
Also learning what the signs and symptoms of Klinefelter syndrome are. Testosterone replacement - In the UK you can get Nebido (injection) which is administered every 3months, they also do a gel and liquid tablets, I've found the injections to work much better for myself Klinefelter's syndrome is a common genetic disorder resulting in testicular failure, variable degrees of androgen deficiency, and infertility. •. Treatment with testosterone can rectify the androgen deficiency but does not improve fertility. •
This is one of the most common Klinefelter syndrome treatments since many of the symptoms stem from low testosterone. Individuals with this condition should see endocrinology to discuss testosterone therapy. It's best to begin testosterone replacement therapy at the time of puberty so that boys develop as normally as possible Testicular biopsy specimen from a 21-yr-old with Klinefelter's syndrome. The peripheral blood karyotype and the karyotype of 100 cells grown from a testicular biopsy sample was 47, XXY. Note focal areas of immature seminiferous tubules interspersed with completely hyalinized tubules and an increase in intersitial tissues The treatment often includes testosterone replacement therapy. Health professionals may also recommend language or speech therapy during childhood to assist affected children achieve the right speech development. Is Klinefelter Syndrome Life-threatening
The syndrome can also be diagnosed before birth, but testing is not routinely done at that time. Treatment of Klinefelter syndrome may include: Genetic counseling to discuss long-term complications; Special education programs (including speech therapy, occupational therapy, or other therapies) Testosterone therap Treatment includes testosterone replacement. This can help improve some of the symptoms but does not have an effect on fertility. The majority of men with Klinefelter's syndrome lead an independent life, forming relationships and getting a normal job Klinefelter syndrome happens when a male is born with an additional X chromosome. This results in smaller-sized testicles, low testosterone levels, and possibly infertility. Complications include. The authors report a case of systemic lupus erythematosus in a hypogonadal male with Klinefelter's syndrome who was treated with testosterone in doses sufficient to normalize the serum level of this hormone to the adult male range. Hematologic and serologic abnormalities, including elevated levels of anti-DNA antibodies and depressed complement. Life-long treatment with testosterone should ensure proper muscle mass, libido, bone mass and the avoidance of being overweight. In addition, it may also improve social function and improve learning abilities. Infertility and Klinefelter syndrome. Until recently it was thought that all males with Klinefelter syndrome were infertile. Recent.
Klinefelter's syndrome Klinefelter's syndrome is the most common cause of testicular failure that results in impairments in both spermatogenesis and—to a lesser extent—testosterone production. This syndrome is the most common sex-chromosome disorder affecting 1 in 500 men across all ethnic groups, but the diagnosis is often delayed becaus Klinefelter Syndrome - the Basics Due to an extra X chromosome in a male (47XXY) Most common sex chromosome condition - (1/500-1000 males) Characteristics can include testicular insufficiency, tall stature, gynecomastia and impaired spermatogenesis - Often requiring testosterone therap -Serum testosterone levels should be measured before start of treatment and periodically during treatment. Patient advice : -Report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections, hoarseness, acne, changes in menstrual periods, or more facial hair
Testosterone replacement therapy is the most common treatment for Klinefelter syndrome. Your physician can prescribe topical creams or injections to restore and stabilize your testosterone levels. Regulating your hormones often relieves many of your symptoms, restoring your health and vitality Patients with Klinefelter syndrome can have successful treatment. This treatment is based on solving three main aspects of KS: hypogonadism, psychosocial issues, and gynecomastia. Hypogonadism is mainly treated by using testosterone replacement therapy
Klinefelter syndrome cannot be cured as there's no way to fix the extra chromosome, but treatments and therapy can help, including: testosterone replacement therapy speech and language therap Klinefelter syndrome is one of the most common genetic disorders affecting one-in-500 to one-in-one-thousand live male births. It affects both physical and intellectual development, and signs and symptoms vary among affected individuals. Common signs and symptoms include small testes, low testosterone levels, decreased muscle mass, enlarged. Genotype and phenotype in Klinefelter syndrome - impact of androgen receptor polymorphism and skewed X inactivation. Int J Androl 2011; 34:e642. Chang S, Skakkebæk A, Trolle C, et al. Anthropometry in Klinefelter syndrome--multifactorial influences due to CAG length, testosterone treatment and possibly intrauterine hypogonadism Clinical review: Klinefelter syndrome--a clinical update. J Clin Endocrinol Metab. 2013; 98(1) Medical treatment is mainly testosterone replacement therapy to alleviate acute and long-term consequences of hypogonadism as well as treating or preventing the frequent comorbidity In my experience no, not until I started TRT. I used to have a home gym before I was diagnosed as KS and I could never improve my bench press. It was always pathetic, maybe 25kg max. I was 6ft 3 inches and 8.5 stone. I was bullied in school for be..
Some genetic conditions, like Turner syndrome or Klinefelter syndrome, can cause high levels of the hormone, as well. [hormone.org] Concentration of testosterone decreased in both PCOS and non-PCOS groups (p 0.01, both) after PRT, as well as glycemia (PCOS, p 0.01; non-PCOS, p 0.02) and body fat percentage [ncbi.nlm.nih.gov] Show info Treatment Options for Klinefelter Syndrome . Androgen therapy (types of testosterone) is the most common form of treatment for Klinefelter syndrome and can have a number of positive effects, including improving sex drive, promoting hair growth, increasing muscle strength and energy levels, and reducing the likelihood of osteoporosis If treatment is given on time, and depending on the degree of gene mutation, most men with Klinefelter syndrome will live a largely symptom-free and normal life. Treatments include: Testosterone replacement therapy (TRT): This involves taking medicines or injections containing testosterone to make up for the deficit in the body If testosterone levels are low, then testosterone therapy may help. It may also help adults. Speech and language therapy. This therapy should start early to avoid social and school problems. XXY (Klinefelter syndrome). Klinefelter Syndrome and Associates website. Available at: The Association for X and Y Chromosome Variations.. Klinefelter Syndrome is a common genetic condition which affects the growth of the testicles ultimately causing smaller than normal testicles resulting in reduced production of testosterone which is an enzyme required for reproduction. Know the causes, symptoms, treatment, and diagnosis of Klinefelter Syndrome
Klinefelter syndrome (KS), also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males. The primary features are infertility and small poorly functioning testicles. Often, symptoms are subtle and subjects do not realize they are affected. Sometimes, symptoms are more evident and may include weaker muscles, greater height, poor coordination, less body hair. Klinefelter syndrome is the presence of two or more X chromosomes plus one Y, resulting in a phenotypic male. Diagnosis is based on clinical findings and is confirmed by cytogenetic analysis. Treatment may include testosterone supplementation
Klinefelter syndrome (KS) is a condition that occurs in men who have an extra X chromosome. Read about the common symptoms and treatments. Treatments include testosterone replacement therapy and breast reduction surgery. If needed, physical, speech, language, and occupational therapy may also help.. Klinefelter syndrome is the most common chromosomal aneuploidy in men (XXY karyotype, 1 in 600 live births) and results in testicular (infertility and androgen deficiency) and nontesticular (cognitive impairment and osteoporosis) deficits. The extent to which skeletal changes are due to testosterone deficiency or arise directly from gene overdosage cannot be determined easily in humans
The cause may be related to the estradiol:testosterone ratio being several fold higher in 47,XXY men than in karyotypically normal men or is possibly due to an increased peripheral conversion of testosterone to estradiol in men with Klinefelter syndrome.  Other neoplasias, occurring in 1.6% of patients, include acute leukemia, Hodgkin and. Klinefelter syndrome, also referred to as XXY condition, is a genetic disease. Klinefelter syndrome affects mostly males. Symptoms include decreased testosterone levels, development of breasts, wider hips, and infertility. Some men with Klinefelter syndrome have no symptoms. Treatment includes educational, therapeutic, and medical therapy